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Gamification of the scientific problem of how biological molecules dock.

BioBlox2D Mobile docking puzzle game

BioBlox2D is a free mobile game for iOS and Android where you have to dock molecules together! Matching different shapes and charges.

Switch, Rotate, Swipe and match the Ligands to create the perfect match for the Receptor. Learn about the fascinating world of bio-molecules and their interactions!


BioBlox3D The ultimate web protein docking game

BioBlox3D is a free online serious game about proteins docking, solve all the levels and share your score!

BioBloxVR Feel the docking experience!

BioBloxVR is a visualization tool for the docking of proteins using virtual reality. It is still under development, if you want to have a try contact us!

About the Project

BioBlox is an interactive platform combining: 3D, 2D and 1D visualisations, interactions, audio feedback (sonification). It is also being designed to become a puzzle gaming which can be played solo or in teams, where for example each team-member controls one molecule (target or candidate for docking).

We address the docking of molecules onto a given target molecule (typically a protein). Such a molecular target offers a complex 3D form with many pockets, holes and textured regions — imagine a moon-like surface wrapped around a 3D folded ribbon—on its bounding surface where other (usually much smaller) molecules can come by and bind to. The process is dynamic in that each such molecule has a bounding form which slightly deforms upon interactions and under the constant bombardment of tiny water molecules (in vivo simulation). This problem is key to the understanding of all cellular processes and in particular to the practical application of drug design.

Crowd sourcing of complex scientific problem is still in its infancy, but is gaining grounds and approval by the scientific communities. Early examples include SETI@home (search for extra terrestrial life) and GalaxyZoo (classification of galaxies). More recent and directly relevant projects are FoldIt and EteRNA: on-line scientific puzzle-solving games about folding proteins and RNA.
The BioBlox project is supported by the BBSRC     

Events & News

  • September 2017: BioBloxVR on show at the next New Scientist Live, ExCeL London : (Sept. 28 - Oct. 1).

  • May 2017: BioBlox suite of games (2D, 3D, VR) at the annual Imperial Festival (May 6-7).

  • February 2017: BioBlox suite of games (2D, 3D, VR) at the annual Schroedinger lecture, Imperial College London (Feb. 1st).

  • December 2016: First version of BioBlox3D in VR shown at the Develop VR day in London.

  • October 2016: BioBlox 2D and 3D to be shown at the Imperial Global Challenge Showcase (27-28 Imperial College White City Campus). Tickets and show information here.

  • September 2016: both the 2D (first time) and 3D versions of BioBlox to be shown at the New Scientist Live event (London ExCeL, September 22-25).

  • July 2016: BioBlox was shown at Develop, the annual UK games industry main meeting (Brighton, July 12-14).

  • May 2016: BioBlox was shown at the Imperial Festival (May 7-8, Imperial College London).

  • March 2016: BioBlox was shown at the 7th VizBi meeting (EMBL, in Heidelberg, Germany March 9-11).

  • December 2015: BioBlox was shown at BiVi 2015, the 2nd annual UK meeting of the Bio-Visualisation Community (Dec. 2-3, the Genome Analysis Centre, Norwich).

  • September 2015: Fringe event on the theme of Designs for Life (Sept. 24, Imperial College London)


Meet the team

The BioBlox group consists of two teams, one based @ the Dept. of Life Sciences @ Imperial College London and one based @ the Dept. of Computing @ Goldsmiths College, also in London, UK. These two teams have worked together since 2007 on various projects, including the History of the Species (SIGGRAPH 2007) and FoldSynth (BioVis 2011). Joining them are Experts and Games Industry & Technology Partners.


Professor Michael Sternberg

Principal Investigator. Director of the Centre for Bioinformatics, Imperial College London.


Professor Frederic Fol Leymarie

co-Director of the MSc CGE. Principal Investigator, Goldsmiths College.


Professor William Latham

co-Director of the MSc CGE. Principal Investigator, Goldsmiths College.


Andy Thomason

Research Associate and senior developer
Goldsmiths College.


Pedro Quijada

Lead Developer
Goldsmiths College.


Elio de Berardinis

Goldsmiths College.


Pablo Larenas

Lead Designer/Artist
Goldsmiths College.


Federico Soncini

Goldsmiths College.


Richard Leinfellner

Product manager. Lecturer on MSc and MA in games. Goldsmiths College.


Dr. Suhail Islam

Research Associate
Imperial College London.


Dr. Alessia David

Research Associate
Imperial College London.


  • Aldo Curtis: MSc internship: developed the initial BioBlox3D PC version under Unity (2015).

  • Paul Eliasz MSc internship: game designer on initial BioBlox3D PC version under Unity (2015).

  • Dr. Ioannis Fillipis: Principal Research Associate. Involved in first phases of development of BioBlox3D (tablet and PC versions) (2014-2017).

  • Kasper Jensen: Research Associate; developed the initial tablet-based BioBlox3D version (2014-15).

  • Martin Juguera: MSc internship; developed initial BioBloxVR version (2016).

  • Dr. Lawrence Kelley: Research Associate (2014).

  • Ian Shaw: Senior consultant, games industry (2014-15).

  • Ciaran Wilson: MA internship: game artist for BioBlox2D (2016).

Contact Us!

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